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Development of Micro-Injector Makes Leaps and Bounds Toward More Effective IVF Procedures

IVF: Injection into Female Egg

Engineering researchers from McMaster University have formulated a palm-sized mirco-injector that could better the procedures of IVF entirely. This palm-sized automated device will ensure higher accuracy and control of movement compared to manual injectors and will be more cost effective. Overall, it will “vastly increase preclinical trials for drug development and genetic engineering.†Better yet, professor Ravi Selvaganapathy, head author of the research, claims that “almost every researcher would be able to have this device at their disposal in their own labs.â€

Here is how it works. “The micro-injector has a cell-wide channel cast on a silicon chip that guides cells and embryos to the injection site. A similar channel guides the injection reagent to a needle as thin as 10 micrometers (one-tenth the diameter of a human hair). The researchers have developed a buckling method to drive the needle through a cell’s pliable outer membrane accurately and to the proper depth. The injection dosage is controlled electrically, as is monitoring of the needle’s position. The researchers have also developed methods to sharpen the needle, ensuring minimal injection damage or interference to the cell.â€

There are many benefits to this new device, one being that micro-injectors can work simultaneously allowing more tests to be conducted in a shorter length of time. Using this device also eliminates the need for microscopes or optical maginification, while ensuring greater accuracy than manually-operated injectors.

The automated tiny injector is ground-breaking on many levels. Here are the specifics:

• “Buckling based actuation of injection needle providing low cost but precise actuation with uniform injection depth and consistent alignment;
• Injection format that could allow needles as small as 100 nanometres, half the size of current injectors, virtually eliminating cell damage and interference with cell functions;
• Electro-osmotic injection which provides electrical control of reagent injected into cell for accurate and uniform dosage;
• Elimination of expensive optical magnification needed for manual injection or to monitor quality control.â€

This exciting creation is a huge step for the science world as a whole, but especially for the reproductive specialists. It could mean huge advancements for the procedures of IVF and testing reproductive cells for causes and solutions to infertility. Professor Selvaganapathy expresses it best, when he asserts, “This device is to drug discovery what the assembly line was to the automobile or the silicon chip to information technology. It turns what was a complex, resource-intensive process available to a few into an automated, predictable, reliable, and low-cost system accessible to almost anyone.â€

About the Author

This article was written by a representative from the Unilab of Dade; it can be found on http://infertilitylabblog.com To check out more ground-breaking articles regarding reproductive issues, click on the link above which will lead you to Unilab's blog. Unilab of Dade is an FDA registered high complexity reproductive medical laboratory that has provided top quality diagnostics and personalized service to the reproductive community for over 20 years. Unilab recognizes the unique testing needs of the reproductive specialist and provides personalized customer service that is unequaled in the laboratory field. We are open 365 days a year and hold most blood samples for one year. Unilab has also developed a comprehensive evaluation and validation process to ensure our testing methods are of the highest quality and sensitivity. Unilab's specialized lab software allows a practice to order individual or multiple tests, customized panels and view patient's tests results all via the web. In order to offer a complete, single source testing service for reproductive specialists, Unilab is also registered with the FDA to perform IVF donor screening. To read more about our practice and specific tests and services that we provide please go to http://www.infertilitylab.com/

How small an object can u see with a light microscope?

How small an object is it possible to see with a light microscope?

The typical compound light microscope is capable of increasing our ability to see detail by 1000 times so that objects as small as 0.1 micrometer (um) or 100 nanometers (nm) can be seen.

Glass electrodes used in nanoscale pump
(PhysOrg.com) -- A team of engineers from the U.S. and South Korea has developed what is believed to be the smallest man-made pump ever built, powered by a glass electrode. The pump is about the same size as a red blood corpuscle.

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